Decline in trials for Alzheimer's disease
More than 99% of drug trials for Alzheimer's disease during the past decade have failed, according to a study.
There is an urgent need to increase the number of potential therapies being investigated, say US scientists.
Only one new medicine has been approved since 2004, they report in the journal Alzheimer's Research & Therapy.
The drug failure rate is troubling and higher than for other diseases such as cancer, says Alzheimer's Research UK.
Dr Jeffrey Cummings, of the Cleveland Clinic Lou Ruvo Center
for Brain Health, in Las Vegas, and colleagues, examined a public
website that records clinical trials.
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Dr Simon Ridley Alzheimer's Research UKThe authors of the study highlight a worrying decline in the number of clinical trials for Alzheimer's treatments in more recent years”
Between 2002 and 2012, they
found 99.6% of trials of drugs aimed at preventing, curing or improving
the symptoms of Alzheimer's had failed or been discontinued.
This compares with a failure rate of 81% for cancer drugs.
The failure rate was "especially troubling" given the rising
numbers of people with dementia, said Dr Simon Ridley, of Alzheimer's
Research UK.
"The authors of the study highlight a worrying decline in the
number of clinical trials for Alzheimer's treatments in more recent
years," he said.
"There is a danger that the high failure rates of trials in
the past will discourage pharmaceutical companies from investing in
dementia research.
"The only way we will successfully defeat dementia is to continue
with high quality, innovative research, improve links with industry and
increase investment in clinical trials."
Experimental models
Dr Eric Hill, of the School of Life and Health Sciences at Aston University, said more research was needed to understand the complex mechanisms behind the disease.
"The development of better experimental models that could be
incorporated into a battery of tests, will not only help us to
understand the changes that occur in the brains of Alzheimer's disease
patients, but also provide tools for the development of new drug
treatments that could slow or stop the onset of disease," he told BBC News.
Alzheimer's disease is the most common form of dementia.
It affects more than 820,000 people in the UK and costs the economy £23bn a year.